Institute of Bioorganic Chemistry, PAS

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Name: Institute of Bioorganic Chemistry, PAS

Address: ul. Noskowskiego 12/14, 61-704 Poznań, Poland

Website: https://www.ibch.poznan.pl/en/home/

Description:

IBCH PAS is one of Poland’s leading scientific institutions. It is distinguished from other research centers by both its interdisciplinarity (chemistry, biology and computer science) and the orientation of its research towards a wide range of issues relating to biogenesis, the structure and functioning of nucleic acids, DNA and RNA. The objects of our studies are viruses, model plants, animals, and humans. Our research is focused especially on topics relating to human diseases (neurodegeneration, cancers, atherosclerosis, viral infections), development and regeneration processes, the search for new medicines and therapeutic targets, and plant physiology. We are also involved in unique genomic and archeogenomic studies.

The high scientific and research potential of IBCH PAS is further evidenced by its unique research infrastructure. The most important elements of this include:

  • one of the most advanced Polish core facilities for structural research, incorporating the Biocrystallography and BioNMR Centers;
  • European Center for Bioinformatics and Genomics, a leading research unit dealing with multiomics, part of the Europe-wide project of the LifeTime Consortium – Revolutionizing Healthcare by Tracking and Understanding Human Cells during Disease;
  • major Poland’s Center for High-Throughput Screening, part of the Europe-wide infrastructure operating under the EU-OPENSCREEN consortium;
  • Poznań Supercomputing and Networking Center (PSNC) one of the largest computing centers in Poland engaged in the development of computer technologies, also an important part of the European IT infrastructure;
  • National Center for Biological and Biomedical Imaging (NEBI), currently is setting up by IBCH PAS in conjunction with the Institute of Experimental Biology PAS.

Disciplines: chemistry, biology, computer sciences

Fields of activity: bioorganic chemistry, biochemistry, molecular biology, systems biology, synthetic biology, bioinformatics

Latest achievements:

  • development of crystallographic models of numerous proteins and nucleic acids;
  • determination of the structure and functions of nucleic acid fragments;
  • determination of factors influencing the occurrence and development of neurodegenerative and neoplastic diseases;
  • modifications of aptamers leading to the improvement of their anticoagulant properties;
  • development of a new method to evaluate the effectiveness of the CRISPR-Cas system;
  • establishing the framework of the "Genomic Map of Poland";
  • discoveries related to ABC transporters in plants;
  • construction of a whole-genome map of DNA copy number variation in Arabidopsis thaliana;
  • development of new bioinformatics tools for studying RNA structures;
  • synthesis and characterization of new nucleotidic prodrugs;
  • development of thermolabile protective groups for DNA and RNA synthesis;
  • establishment of the High-Throughput Screening platform;
  • implementation of a number of national, European and global projects (four Crystal Brussels Sprout Awards);
  • four projects located on the Polish Map of Research Infrastructure.


Research facilities:

Scientists doing their studies in IBCH PAS are supported with a number of specialized laboratories operated by experienced employees using modern equipment. The Laboratories are grouped in three centers:

  • Structural Biology Center (incl. Laboratory of Subcellular Structures Analyses, Laboratory of Protein Engineering and Laboratory of NMR)
  • Multiomic Center (incl. Laboratory of Genomics, Laboratory of Cell and Tissue Cultures, Laboratory of Model Animal Organisms, Laboratory of Model Mammal Organisms, Laboratory of Mass Spectrometry, Laboratory of Bioinformatics and Laboratory of Molecular Diagnostics)
  • High-Throughput Screening Center (incl. Laboratory of High-Throughput Analyses, Laboratory of Nucleic Acids Derivatives Synthesis and Laboratory of Molecular Tests)

These facilities offers scientific research in the fields of, e.g.:

  • organic synthesis, including modified nucleobases, nucleosides, and nucleotides;
  • NMR spectroscopy - 1D and 2D NMR spectra of various nuclei (1H, 13C, 19F, 15N, 29Si, 31P, 11B, etc.);
  • mass spectra, analysis of small molecules and proteins;
  • characterization, production and purification of recombinant proteins;
  • confocal microscopy and flow cytometry;
  • DNA and RNA sequencing;
  • cell lines and tissue cultures.

Computational support is provided by Poznan Supercomputing and Networking Center.

Contact person:

Professor Michał Sobkowski
Deputy  Director  for  Scientific  Affairs
dyrektor.naukowy@ibch.poznan.pl
(+48 61) 852 85 03 ext. 1182